abstract：:The present study was conducted to evaluate the efficacy of paternal lymphocyte (PL) immunotherapy and its relation with the development of mixed lymphocyte reaction blocking antibodies (MLR-Bf) and the success of pregnancy outcome in women with recurrent spontaneous abortion (RSA). A total of 124 women with unknown c...

journal_title：International immunopharmacology

authors： Pandey MK,Agrawal S

更新日期：2004-02-01 00:00:00

abstract：:Effects of a topical corticosteroid drug, diflucortolone valerate, on the mRNA expressions for four CC- and four CXC-chemokines, which have been reported to be associated with recruitment of different kinds of proinflammatory and inflammatory cells, were investigated by RT-PCR in mice with 2,4,6-trinitrochlorobenzene ...

journal_title：International immunopharmacology

authors： Mitsui G,Hirano T,Niwano Y,Mitsui K,Ohara O,Yanagihara S,Kato M

更新日期：2004-01-01 00:00:00

abstract：:By co-expressing glucocorticoid receptor (GR) and transcriptional reporter systems in GR-deficient Cos-7 cells, we profiled potency and efficacy of a panel of GR ligands as a function of GR expression levels (density). Our results show that potency and efficacy for GR full agonists, such as dexamethasone, in these tra...

journal_title：International immunopharmacology

authors： Zhao Q,Pang J,Favata MF,Trzaskos JM

更新日期：2003-12-01 00:00:00

abstract：:In this study, we report evidences that Mycobacterium tuberculosis (MTB)-induced apoptosis in macrophages is reduced by a broad-spectrum hydroxamic acid-based matrix metalloproteinase (MMP) inhibitor, Batimastat (BB-94). In particular, we show that BB-94 administration to MTB-infected macrophages inhibits apoptosis an...

journal_title：International immunopharmacology

authors： Santucci MB,Ciaramella A,Mattei M,Sumerska T,Fraziano M

更新日期：2003-11-01 00:00:00

abstract：:This work evaluated the in vitro influence of digitalis and furosemide on the phagocytic function of neutrophils of healthy individuals. Phagocytosis of Saccharomyces cerevisiae by peripheral blood neutrophils of 20 healthy individuals was assessed in the absence or presence of deslanoside or furosemide. The Wilcoxon ...

journal_title：International immunopharmacology

authors： Muniz-Junqueira MI,Mota LM,Aires RB,Junqueira LF Jr

更新日期：2003-10-01 00:00:00

abstract：:Analgesic and anti-inflammatory applications for non-peptide bradykinin (BK) B2 receptor antagonists have been documented in rats. However, very large species differences in affinity were also noted within this class of drugs, making the preclinical development of relevant drugs difficult. Bradyzide is a potent antago...

journal_title：International immunopharmacology

authors： Marceau F,Fortin JP,Morissette G,Dziadulewicz EK

更新日期：2003-10-01 00:00:00

abstract：:A novel method of large-scale chromatography has been developed to improve recovery and purity of immunoglobulin G (IgG) from pooled plasma. The current study compares safety, toxicity and efficacy of two intravenous immunoglobulin products: a novel formulation, IGIV caprylate/chromatography (IGIV-C; Gamunex, 10%) and...

journal_title：International immunopharmacology

authors： Roifman CM,Schroeder H,Berger M,Sorensen R,Ballow M,Buckley RH,Gewurz A,Korenblat P,Sussman G,Lemm G

更新日期：2003-09-01 00:00:00

abstract：:Recent experimental data suggest that immunity can be activated to prevent tumors. The rationale for prevention is strong because the setting is one endowed with an immune system that is neither impaired by tumor and treatment-induced suppression, nor tolerant to tumor-associated antigens. Oncogenic growth factor rece...

journal_title：International immunopharmacology

authors： Forni G,Curcio C,Spadaro M,Iliffe J,Quaglino E,Di Carlo E,Musiani P,Lollini PL

更新日期：2003-08-01 00:00:00

abstract：:Apoptosis plays an important role in immune responses, but little is known about its involvement in contact hypersensitivity (CH). In this study, we have investigated the role of Fas/Fas ligand (FasL)-mediated apoptosis in the pathogenesis of CH. Mice were sensitized by one topical application of 100 microl of 3% oxaz...

journal_title：International immunopharmacology

authors： Xu B,Bulfone-Paus S,Aoyama K,Yu S,Huang P,Morimoto K,Matsushita T,Takeuchi T

更新日期：2003-07-01 00:00:00

abstract：:Understanding of oligodendrocyte precursor cells and their role in the generation of oligodendrocytes in developing and adult rodents has been considered, particularly much less is known about aged-rodent oligodendrocyte precursor cells and their cell lineage. In this present study, we have developed oligodendrocyte c...

journal_title：International immunopharmacology

authors： Kobayashi J,Seiwa C,Sakai T,Gotoh M,Komatsu Y,Yamamoto M,Fukutake M,Matsuno K,Sakurai Y,Kawano Y,Asou H

更新日期：2003-07-01 00:00:00

abstract：:Neutrophil apoptosis is a constitutive process that can be enhanced or delayed by various stimuli. In this study, the effect of brefeldin A (BFA), which affects the biological process of secretion, on constitutive and delayed apoptosis of neutrophils was investigated. Neutrophil apoptosis was determined after culturin...

journal_title：International immunopharmacology

authors： Lee MJ,Park JY,Lee SY,Lee JS,Jung DK,Bae YS,Kwak JY

更新日期：2003-06-01 00:00:00

abstract：:Herbal medicine, Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.), was administered to mice with Behcet's disease (BD)-like symptoms induced by herpes simplex virus (HSV). BD is a chronic recurrent inflammatory disease. Herba Taraxaci (6 mg) was administered alone or in combination with 2 microg of colchicine to BD-l...

journal_title：International immunopharmacology

authors： Sohn S,Bang D,Lee SI,Kim YA,Lee ES,Ha JY,Kim JH,Choi SY,Lee S

更新日期：2003-05-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure results in an increased percentage of CD11b(+) (Mac-1(+)) cells in the spleens of mice challenged with P815 tumor cells, coincident with a failure of the mice to generate allospecific CD8(+) CTL activity. Since CD11b(+)Gr-1(+) myeloid suppressor cells (MSC) have been...

journal_title：International immunopharmacology

authors： Choi JY,Oughton JA,Kerkvliet NI

更新日期：2003-04-01 00:00:00

abstract：:It is known that the tissue kallikrein-kinin system is located in the cardiac tissue, and the lack of this system in the cardiac tissue might induce cardiac dysfunctions. In this study, we investigated the potential role of tissue kallikrein and Trasylol, an inhibitor of tissue kallikrein, on survival time with acute ...

journal_title：International immunopharmacology

authors： Sharma JN,Abbas SA,Yusof AP,Shah RP

更新日期：2003-03-01 00:00:00

abstract：:Cyclosporine A (CsA) is the first immunosuppressant universally used in allotransplantation. However, it has been demonstrated that this drug produces side effects in several organs, particularly in the kidney and in the heart. Since the immunosuppressive therapy induces myocardial toxicity, the aim of this study was ...

journal_title：International immunopharmacology

authors： Bianchi R,Rodella L,Rezzani R

更新日期：2003-03-01 00:00:00

abstract：UNLABELLED:Dendritic cells (DC) were implicated as the mediators of primary stimulation of the immune response against donor antigen. Anti-lymphocytes globulin (ALG) and anti-thymocytes globulin (ATG) antibodies have been widely used as an immunosuppressive agent in the treatment and prevention of rejection after organ...

journal_title：International immunopharmacology

authors： Monti P,Allavena P,Di Carlo V,Piemonti L

更新日期：2003-02-01 00:00:00

abstract：:The present study was conducted to determine if selected events in glucocorticoid receptor (GR) signaling that have been identified using mostly in vitro approaches with synthetic glucocorticoids also occur in mature T cells exposed to relevant levels of corticosterone in vivo. In contrast to effects reported in vitro...

journal_title：International immunopharmacology

authors： Pruett SB,Fan R,Zheng Q

更新日期：2003-01-01 00:00:00

abstract：:Previous work has shown that in vitro thymulin treatments have the ability to enhance natural killer (NK) cell cytotoxicity. The purpose of the experiments presented here was to examine the in vivo effects of thymulin on avian NK cell activity in response to a viral infection. Five and a half-week-old K-strain chicken...

journal_title：International immunopharmacology

authors： Oliver MA,Marsh JA

更新日期：2003-01-01 00:00:00

abstract：:To study the intramolecular signal transduction, we performed single point and cassette mutations in transmembranal and intracellular regions of the bradykinin B2 receptor. We studied the influence of the two intramembranal Cys residues at positions 304 and 348, the role of Arg at position 177 in the highly conserved ...

journal_title：International immunopharmacology

authors： Mueller S,Liebmann C,Reissmann S

更新日期：2002-12-01 00:00:00

abstract：:Human plasma kallikrein (huPK) is a serine proteinase involved in many biological processes including those of the kallikrein-kinin system. The action of huPK on kininogen results in bradykinin (BK) release, a potent mediator of inflammatory responses. BK generation may be influenced by several agents, and the aim of ...

journal_title：International immunopharmacology

authors： Gozzo AJ,Nunes VA,Carmona AK,Nader HB,von Dietrich CP,Silveira VL,Shimamoto K,Ura N,Sampaio MU,Sampaio CA,Araújo MS

更新日期：2002-12-01 00:00:00

abstract：:We had reported that in the ischemic heart, locally formed bradykinin (BK) and angiotensin II (Ang II) activate B2- and AT1-receptors on sympathetic nerve terminals (SNE), promoting reversal of the norepinephrine (NE) transporter in an outward direction (i.e., carrier-mediated NE release). Although both BK and Ang II ...

journal_title：International immunopharmacology

authors： Levi R,Silver RB,Mackins CJ,Seyedi N,Koyama M

更新日期：2002-12-01 00:00:00

abstract：:The objective of this study was to define the role of complement activation in the acute and transient toxicities associated with administration of phosphorothioate oligonucleotides in monkeys. In the absence of complement inhibitor, complement activation blocker-2 (CAB-2), i.v. infusion of 20 mg/kg ISIS 2302 produced...

journal_title：International immunopharmacology

authors： Henry SP,Beattie G,Yeh G,Chappel A,Giclas P,Mortari A,Jagels MA,Kornbrust DJ,Levin AA

更新日期：2002-11-01 00:00:00

abstract：:The aim of this study was to investigate whether fever and antipyretic drugs had an adverse effect on human polymorphonuclear leukocyte (PMN) functions (phagocytic and intracellular killing activity). Twenty febrile children with an axillary temperature of 39-40 degrees C and 20 healthy children without fever were inc...

journal_title：International immunopharmacology

authors： Gürer US,Palanduz A,Gürbüz B,Yildirmak Y,Cevikbaş A,Kayaalp N

更新日期：2002-10-01 00:00:00

abstract：:It has been recently reported that nicotine, the addictive component of tobacco, is an important modulator at the level of immune cell apoptosis or programmed cell death. Apoptosis is a process that helps maintain the homeostasis of the vascular endothelium and vascular smooth muscle cells, and alteration of the apopt...

journal_title：International immunopharmacology

authors： Hakki A,Friedman H,Pross S

更新日期：2002-09-01 00:00:00

abstract：:We investigated whether Candida beta-D-glucan (CSBG) alters the maturation of dendritic cells (DCs). DC phenotypes were analyzed using FACScan. The expression of surface molecules, including major histocompatibility complex (MHC) classes I and II, as well as CD80 and CD86, increased on DCs that were stimulated with li...

journal_title：International immunopharmacology

authors： Kikuchi T,Ohno N,Ohno T

更新日期：2002-09-01 00:00:00

abstract：:Endomorphin-1 is a recently isolated endogenous opioid peptide, and potent and selective high affinity mu-opioid receptor agonist. We evaluate the role of endomorphin-1 on macrophage functions. Endomorphin-1 potentiated macrophage adhesion and the expression of adhesion molecule Mac-1 on macrophages. However, endomorp...

journal_title：International immunopharmacology

authors： Inui Y,Azuma Y,Ohura K

更新日期：2002-07-01 00:00:00

abstract：:The effect of melatonin on the expression of genes previously correlated to T lymphocyte activation (HLA-DRB, thymosin beta 10 (beta-Tim)) and to Lymphokine Activated Killer (LAK) activity (beta-Tim, Tumour Rejection Antigen (TRA 1), nRap 2) was investigated in phytohemagglutinin (PHA)-stimulated human lymphocyte cult...

journal_title：International immunopharmacology

authors： Capelli E,Campo I,Panelli S,Damiani G,Barbone MG,Lucchelli A,Cuccia M

更新日期：2002-06-01 00:00:00

abstract：:We have earlier reported that ethanolic extract of Boerhaavia diffusa, a plant used in Indian traditional system of medicine, significantly inhibits the cell proliferation. This led us to evaluate the immunomodulatory properties of this plant extract on various in vitro tests such as human natural killer (NK) cell cyt...

journal_title：International immunopharmacology

authors： Mehrotra S,Mishra KP,Maurya R,Srimal RC,Singh VK

更新日期：2002-06-01 00:00:00

abstract：:Vimang is an aqueous extract of Mangiferia indica L., traditionally used in Cuba as an anti-inflammatory, analgesic and antioxidant. In the present study, we investigated the effects of Vimang and of mangiferin (a C-glucosylxanthone present in the extract) on rat macrophage functions including phagocytic activity and ...

journal_title：International immunopharmacology

authors： García D,Delgado R,Ubeira FM,Leiro J

更新日期：2002-05-01 00:00:00

abstract：:There is increasing evidence that neuronal factors can affect hematopoietic cell proliferation. Endogenous opioids with specificity for several opioid receptor classes were tested for their ability to inhibit murine and human hematopoietic progenitor cell proliferation. Tyr-MIF, an opioid tetrapeptide (H-Tyr-Pro-Leu-G...

journal_title：International immunopharmacology

authors： Horowitz D,Callahan JF,Pelus LM,Fukuda S,King AG

更新日期：2002-04-01 00:00:00

abstract：:We investigated effects of fosfomycin (FOM) on neutrophil function, specifically the oxidative burst and adhesion molecule expression (CD11b/CD18, or MAC-1) using flow cytometry assay. Preincubation of polymorphonuclear leukocytes (PMNL) with FOM from 1 to 100 microg/ml prior to stimulation by phorbol 12-myristate 13-...

journal_title：International immunopharmacology

authors： Hamada M,Honda J,Yoshimuta T,Fumimori T,Okamoto M,Aizawa H

更新日期：2002-03-01 00:00:00

abstract：:Recent studies on the immunosuppressive effects of ultraviolet radiation (UVR) and the related resistance to infections in rodents and humans are presented. The waveband dependency of trans-to-cis isomerisation of urocanic acid in the stratum corneum and the role of DNA damage in UVR-induced erythema and immunosuppres...

journal_title：International immunopharmacology

authors： Termorshuizen F,Garssen J,Norval M,Koulu L,Laihia J,Leino L,Jansen CT,De Gruijl F,Gibbs NK,De Simone C,Van Loveren H

更新日期：2002-02-01 00:00:00

abstract：:Echinacea plant extract is widely used for the prevention and the treatment of upper respiratory tract infections. However, the active components in the herb, their optimal dosages and their in vivo effects are still undefined. Using male Sprague-Dawley rats (425-475 g), an in vivo study was conducted to examine the i...

journal_title：International immunopharmacology

authors： Goel V,Chang C,Slama JV,Barton R,Bauer R,Gahler R,Basu TK

更新日期：2002-02-01 00:00:00

abstract：:Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes. In addition to the bacterial peptide fMLF and the...

journal_title：International immunopharmacology

authors： Le Y,Yang Y,Cui Y,Yazawa H,Gong W,Qiu C,Wang JM

更新日期：2002-01-01 00:00:00

abstract：:This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/...

journal_title：International immunopharmacology

authors： Tokunaka K,Ohno N,Adachi Y,Miura NN,Yadomae T

更新日期：2002-01-01 00:00:00

abstract：:Glucocorticoids (GCs) have been considered to regulate immune cell systems through induction of apoptosis in thymocytes and mature peripheral-blood lymphocytes. Here we report that apoptosis induced by cortisol in mitogen-activated peripheral-blood mononuclear cells (PBMC) is suppressed by cortisone, an oxidized metab...

journal_title：International immunopharmacology

authors： Hirano T,Horigome A,Takatani M,Oka K

更新日期：2001-11-01 00:00:00

abstract：:It is recognized that macrophages in peripheral tissues often proliferate under pathological conditions such as tumors, inflammation and atherosclerosis. Because the growth state of macrophages is believed to be a factor regulating the pathological process of the diseases, substances that regulate macrophage growth or...

journal_title：International immunopharmacology

authors： Yui S,Ubukata K,Hodono K,Kitahara M,Mimaki Y,Kuroda M,Sashida Y,Yamazaki M

更新日期：2001-10-01 00:00:00

abstract：:For many years, it has been recognized that Mycoplasma infection affects the host's immune system in different ways. In this work, experiments were performed to characterize the influence of Mycoplasma pulmonis infection on various immunological parameters and to follow the kinetics of their variations. A Balb/c mouse...

journal_title：International immunopharmacology

authors： Romero-Rojas A,Ponce-Hernández C,Ciprián A,Estrada-Parra S,Hadden JW

更新日期：2001-09-01 00:00:00

abstract：:A lipoteichoic acid-related molecule (OK-PSA) isolated from OK-432, a penicillin-killed Streptococcus pyogenes, is a potent inducer of Th1 cytokines, and elicits anti-cancer effect in tumor-bearing mice. Toll-like receptor (TLR) 4 is a member of the recently identified toll-like receptor family of proteins that has be...

journal_title：International immunopharmacology

authors： Okamoto M,Oshikawa T,Ohe G,Nishikawa H,Furuichi S,Tano T,Moriya Y,Saito M,Sato M

更新日期：2001-09-01 00:00:00

abstract：:There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kinina...

journal_title：International immunopharmacology

authors： Dellalibera-Joviliano R,Reis ML,Donadi EA

更新日期：2001-09-01 00:00:00